Safety Pharmacology

///Safety Pharmacology
Safety Pharmacology 2017-07-04T10:25:31+00:00

Safety Pharmacology Studies

Safety pharmacology studies provide important information to assess the impact of your compound in terms of its potential side effects on major organ systems. MPI Research scientists apply their decades of experience and technical innovation in safety pharmacology to identify and characterize potential functional safety risks.

MPI Research provides

  • Integrated safety pharmacology assessments, from cellular to whole-animal studies
  • A consultative approach to the unique needs of each client and compound, with the flexibility and experience to support the evaluation of specialized endpoints in your safety pharmacology study
  • Experimental designs to comprehensively and seamlessly evaluate functional safety and traditional toxicology endpoints

In purpose-built facilities incorporating the latest data systems technology, the MPI Research safety pharmacology team provides a full range of functional testing services. We conduct safety pharmacology studies with fully validated systems that are in compliance with International Conference on Harmonisation (ICH) Tripartite Guidelines (S7A, S7B), and routinely innovate and implement industry best practices.

  • Remote telemetry monitoring in freely moving animals, including all contemporary models, with calibrated continuous data collection, using appropriate analytical methods for quantitative and qualitative data
  • Fully validated, non-invasive remote telemetry monitoring system for large animals provides an alternative to surgical instrumentation
  • hERG assessment via whole cell patch clamp
  • Restrained/anesthetized models
  • Cardiac output/arterial flow
  • Vascular/peripheral resistance
  • Ventricular and pulmonary arterial pressure
  • Ultrasound/echocardiography

  • Rate, volume, supplemental derived respiratory mechanic parameters, and blood gas analyses
  • Whole-body, head-out, and dual-chamber plethysmography in small animals
  • Remote, calibrated telemetry monitoring in freely moving animals with continuous data collection
  • Plethysmography in large animals
  • Lung resistance and compliance measures in anesthetized rodents

  • Functional Observational Battery (FOB) for small and large animals
  • Quantitative motor performance tests
  • Higher order neurofunctional endpoints
  • CNS electrophysiology (EEG-based sensory, motor, and generalized assessments, including quantitative methods)

  • Urinary screening
  • Definitive functional evaluations in multiple species

  • Gastric emptying in rodents
  • Gastrointestinal transit in multiple species