Orthopaedic 2017-07-04T10:25:01+00:00

Orthopedic Research

One out of every six visits to a United States hospital involves a musculoskeletal disorder – a strain or sprain, a fracture, or a more serious disease, such as osteoarthritis. More than half of all people above age 50, in developed countries, have at least one of these disorders, affecting bones, muscles, ligaments, tendons, and nerves, often in very painful ways.

The societal effects of orthopaedic conditions are not limited to health. A 2004 study estimated the economic impact in the United States at a staggering $849 billion. Furthermore, the long-term outlook is no brighter, as baby boomers age and these conditions become more prevalent.

Public and private research organizations, including the National Institutes of Health, are paying more attention to musculoskeletal disorders, but, resources still remain tight. Thus, researchers need superior, cost-effective discovery and preclinical testing services.

MPI Research is one of the world’s premier contract research organizations (CROs) supporting preclinical drug and device discovery and development. Our experienced, highly-skilled staff provides orthopaedic surgical capabilities ranging from simple to complex. Through a combination of technology, state-of-the-art facilities, and expertise, MPI Research provides exceptional research solutions, with ease and speed of study initiation across many animal species.

Our collaborative approach ensures Sponsors to understand the critical aspects of a promising device or drug candidate, helping them make decisions on developing those with the greatest potential.

  • Articular cartilage repair
  • Anterior cruciate ligament (ACL) repair
  • Osteoarthritis (OA) models
  • Meniscal repair/replacement
  • Reconstruction/fixation of ligaments and tendons
  • Critical/non-critical segmental defects
  • Tibial/femoral/ulnar osteotomy models
  • Maxillofacial/mandibular defects
  • Dental implants
  • Autograft/allograft/bone graft substitute implantation
  • Bone ingrowth for joint replacement
    • Non-weight-bearing (axial, transcortical) defects
  • Bone cement, putty, implantation
  • Critical size defect models with mechanical testing
    • Radial defect
    • Ulnar defect
    • Femoral defect
    • Calvaria defect
    • Tibial defect
  • Spinal surgery/bone reconstruction
  • Posterolateral/interbody fusion
  • Intervertebral disc reconstruction
  • Discectomy/disc replacement
  • Spine intervention




Studies performed in the past 2 years