Ophthalmology

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Ophthalmology 2017-07-04T10:24:45+00:00

MPI Research Grows Ophthalmology Services with Director Addition
MPI Research announced today it will further develop its ophthalmology practice, starting with the recent hire of Josh Bartoe, DVM, MS as Director of Ophthalmology Services.

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Among the worst vision-threatening conditions are age-related macular degeneration (AMD), the leading cause of blindness among people over age 55 in developed nations, and diabetic retinopathy (DR). In the United States alone, 13 million people have some stage of AMD and 45% of type 2 diabetics have a form of DR. Developing effective new treatments for AMD, DR, and myriad ocular diseases means researchers need both accurate safety and efficacy models, and experienced staff skilled in dosing procedures and end-point data collection ophthalmology services. At MPI Research, we provide the full spectrum of ocular expertise. Our team has extensive experience with ocular formulation preparation, ocular dosing routes, clinical ophthalmology examination techniques, specialty diagnostic procedures, tissue micro-dissection, PK/biodistribution, and ocular histopathology.

Sponsors return to us for experience, quality, precision, and teamwork needed to advance new ocular treatments and cures. MPI Research is ready to “open your eyes” to the ways we can meet your study needs in ophthalmology.

  • On-site ACVO board-certified veterinary ophthalmologist
  • Slit-lamp biomicroscopy
  • Indirect and direct ophthalmoscopy
  • Hackett-McDonald, Draize, and customized scoring protocols
  • Corneal fluorescein staining
  • Tonometry, gonioscopy
  • Schirmer tear/phenol red thread testing
  • Streak retinoscopy
  • Ocular dosing routes including intravitreal, intracameral, subconjunctival/tenons, subretinal, topical, and systemic
  • Heidelberg Spectralis platform
    • Spectral-domain optical coherence tomography (SD-OCT); retinal layer segmentation
    • Confocal scanning laser ophthalmoscopy (cSLO)
    • Angiography (fluorescein, indocyaine green)
  • Roland Consult Electroretinography (ERG)
    • Dark-adapted, light-adapted, flicker responses
    • ISCEV standard, customized protocols
  • Fundus photography
    • Phoenix Research Labs, Micron IV—mice and rats
    • Clarity Medical Systems, RetCam Shuttle—rabbits, dogs, pigs, and nonhuman primates
  • Uveitis models—rats and rabbits
  • Retinal degeneration
  • Documentable ocular exams, scoring protocols
  • Laser-induced choroidal neovascularization models
  • Ophthalmic surgical expertise
    • Sustained release devices
    • Glaucoma shunts
    • Intraocular lens implants
    • Customized procedures
  • Ocular pharmacokinetics and biodistribution
    • Up to 15 ocular tissues by dissection
    • Detection by radioactivity, LC/MS/MS, ELISA, etc.
    • Ocular autoradiography (2D and 3D)
    • PET and SPECT available
  • Ocular histopathology
    • 15 ACVP board-certified veterinary anatomic pathologists, extensive ocular disease experience
    • Validated immunohistochemical labeling of biomarkers in ocular tissue
    • Retinal flat-mounts
  • Aqueous/vitreous humor collections, biomarker quantification