General Toxicology

Home/Services/Drug Safety/General Toxicology
General Toxicology 2017-07-04T10:26:10+00:00

DSE-gentox1

Pharmaceutical and biopharmaceutical companies use preclinical toxicology studies to evaluate the safety of new drug candidates. The pressure to complete these studies accurately, quickly, and economically, while adhering to FDA and international regulatory requirements, is greater than ever. With the growing diversity of products in development, evaluating the safety of a compound has become increasingly complex.

Our scientific and technical staff represent a wide range of disciplines, and dedicate their time and skills to your program—from test material preparation through data interpretation—working closely with you, while remaining flexible and responsive to your needs. Their extensive experience with general toxicology studies of increasing complexity and their ability to respond to and troubleshoot unexpected issues, enables you to achieve fast regulatory compliant data.

MPI Research delivers a full range of general toxicology services, supported with formulation development and analysis, and complete toxicokinetic analysis and interpretation. Routine collaboration with our in-house experts in bioanalytical/analytical sciences, immunology, clinical and anatomic pathology services, safety pharmacology, and other disciplines enables us to conduct studies with integrated endpoints for faster, more cost-efficient results, and to provide a comprehensive integrated study report.

MPI Research meets your challenges with

  • A knowledgeable team of Study Directors who serve as your collaborative partners
  • Flexible study designs to expedite your program
  • Optimal timelines
    • Studies are always completed within tight timeframes, typically in advance of schedule.
    • On average, we complete an IND package within six months.
  • An outstanding record of regulatory compliance
  • Extensive historical database to help discern test article-related effectsfrom background findings

  • Pilot/lead optimization
  • Acute
  • Subchronic
  • Chronic
  • Carcinogenicity/oncogenicity

  • Rodents (rats, mice, hamsters)
  • Canines
  • Nonhuman primates (cynomolgus and rhesus)
  • Felines
  • Swine (Göttingen and farm pigs)
  • Rabbits
  • Guinea pigs
  • Ferrets

  • Oral
    • Gavage
    • Dietary
    • Capsule/tablet
    • Drinking water
  • Dermal
  • Intradermal
  • Parenteral
    • Intramuscular
    • Intraperitoneal
    • Intravenous
    • Subcutaneous
  • Ocular
  • Sublingual
  • Intravaginal
  • Rectal
  • Intranasal

  • Integrated, companywide Provantis™ system for efficient, accurate data capture, entry, and reporting
    • In-life
    • Clinical pathology
    • Necropsy
    • Histopathology
    • Nexdocs
      • Capa-based system
  • Veterinary Management System (VMS)
  • Full standard for the exchange of preclinical data (SEND) package production

  • Small molecules
  • Recombinant proteins, antibodies, peptides, other biopharmaceuticals
  • Vaccines
  • Food additives
  • Veterinary products
  • Industrial chemicals
  • Agro-chemicals
  • Nanoparticles