Risks and Effects of Ototoxic Medications

//Risks and Effects of Ototoxic Medications

Risks and Effects of Ototoxic Medications

Bringing a new drug to market is not a simple task and due to regulations and high costs associated with the process, drug developers often pass on conducting optional testing. Ototoxicity is one example of a frequently forgone test as it’s not required by the FDA for medications that are not administered into the ear. Ototoxicity has been defined as the tendency of certain therapeutic agents and other chemical substances to cause functional impairments and cellular degeneration of the tissues of the inner ear. Today, more than 200 drugs on the market can impact hearing. Additionally, one of the largest contributors to hospitalizations is fall-related injuries in elderly patients associated with disorders of vestibular function linked to drug-induced toxicities. Similarly, tinnitus (noise or ringing in the ear) affects 35 to 50 million adults and is believed to be a side effect of several kinds of medications.

What may seem to be trivial drug-induced toxicity has the potential to drastically impact quality of life for an individual. Drugs meant to treat one condition can become the source of interference in the activities of daily living, which may cause patients to stray from their treatment plans.

While ototoxicity is a highly specialized and often overlooked area of science (most toxicology textbooks don’t even mention the topic), the effects can be devastating. The changes in a person’s quality of life, physical injuries linked to home falls, and the highly disruptive noise of tinnitus or hyperacusis are a challenge for millions of patients who are prescribed ototoxic drugs.

As therapies in development continue to become more sophisticated and selectively targeted, reducing unwanted, off-target general toxicity, it is important that pharmaceutical developers carefully consider special categories of unintended toxicity that historically have drawn relatively little attention in safety testing and clinical practice. Ototoxicity is one such category of concern and should be carefully considered and monitored to ultimately improve patient quality of life.

By | 2017-08-16T13:07:50+00:00 August 16th, 2017|Blog|Comments Off on Risks and Effects of Ototoxic Medications

About the Author:

MPI Research, with global headquarters in Mattawan, Mich., provides safety evaluation, discovery, bioanalytical and analytical services to the biopharmaceutical, medical device, animal health, and chemical industries. The company offers comprehensive imaging solutions including preclinical imaging, radiochemistry, and data analysis. Scientific knowledge and experience, responsiveness, integrity, trust, teamwork, and dedication to strong and enduring Sponsor relationships are the defining attributes that characterize MPI Research as a high-performance, high-quality organization that is committed to bringing safer and more effective products to the world.