To assure
that MPI Research Sponsors receive expert
evaluation and interpretation of pathological
data, the company combines four laboratories – Clinical
Pathology, Anatomic Pathology, Histology
and Necropsy – as part of its general
pathology services. A team of board-certified
veterinary clinical pathologists and trained
technicians utilize a multi-head microscope
for in-house pathological reviews, briefings
with Sponsors, peer reviews and for collaborative
consultations with outside experts.
Services/Capabilities
Clinical
Pathology
The clinical pathology facilities of MPI
Research occupy approximately 3,200 square
feet/279 square meters. The technological
and human expertise available enables MPI
Research provide expert evaluation and interpretation
of data and to produce quality results for
blood counts, urinalyses, and chemistry panels.
Microscopic bone marrow evaluations are conducted
routinely. More than one million tests are
conducted each year, with the following clinical
evaluations being routinely performed:
- Hematology
- Coagulation
- Urinalysis
- Serology
- Clinical chemistry
- Blood gas
- Fluid analysis
- Parasitology
The following specialized
equipment is available within the clinical
pathology facilities:
- Olympus AU640™
- Olympus AU2700™
- Bayer Advia® 120
& Bayer Advia® 2120 Hematology
Systems
- Bayer CLINITEK®
- Bayer CLINITEK 500 ®
- Bayer Rapidpoint™
- Stago co-ag analyzer
- Atlas Urinalysis
Using Clinical Pathology
Supervisor and Worksheet Manager, in conjunction
with Provantis NT™, MPI Research is
able to efficiently and comprehensively capture
data electronically, as well as necropsy
and microscopic pathology observations. These
functions results in increased reporting
speed and eliminate opportunities for data
entry error.
A large historical control database is maintained
for multiple animal species. Experienced
consultants conduct formal peer reviews and
informal peer reviews are routinely held
by the MPI Research staff pathologists to
ensure that our Sponsors receive accurate,
consistent, and top quality pathology data.
MPI Research also offers clinical pathology
testing for samples sent from another site.
Anatomic Pathology
The area of anatomic pathology at MPI Research
provides expert evaluation and interpretation
of pathology data. The use of the Pathology
module, Provantis™, allows the pathologist
to review necropsy and microscopic pathology
observations, resulting in increased production
speed of draft reports and eliminating opportunities
for error during data input. Formal peer
reviews are conducted by experienced consultants
and informal peer reviews are routinely conducted
by MPI Research staff pathologists to ensure
accurate, consistent high quality pathology
data.
Histology
The histology laboratory at MPI Research, occupying 6,000 square feet/557 square
meters, has the capacity to process approximately 150,000 tissues monthly.
Included within the Histology Laboratory is a plastics
embedding facility (GMA, MMA, Spurs) that also provides histomorphometric
analysis. The Pathology module of ProvantisT supports the management of comprehensive
histopathology data, including mass tracking and organ weights. Capabilities
within the histology laboratory at MPI Research, which has the capacity to
process 1,800,000 tissues annually, include:
- Routine preparation of paraffin-embedded
and frozen sections
- Numerous special staining procedures
in addition to immunofluorescence and immunohistochemical
techniques
- Plastics embedding capabilities (GMA,
MMA, Spurs), including histomorphometric
analysis, immunohistochemistry and wound
tensile strength analysis
- Separate but coordinated areas for tissue
trimming, processing and embedding, microtomy,
staining, review/quality control, special
stain preparation and wet tissue storage
and services
Necropsy
An experienced veterinary pathologist has
hands-on supervision of all necropsies
that are at MPI Research. The 12,000 square-foot/1,115
square meter pathology facility houses
a newly designed necropsy suite equipped
with customized workstations, with small
and large animal holding rooms. Necropsy
services and capabilities include:
- Forty-Four custom-designed
workstations for small-animal necropsies
- Six custom-designed, full-size
hydraulic, down-draft necropsy tables for
large-animal necropsies, providing capacity
for 15 large-animal workstations
- Routine necropsy examinations
of animals ranging from rodents to non-human
primates and swine
- Routine and specialized
procedures, including whole-body and upper-body
perfusions, and perilymphatic perfusions
of the inner ear for ototoxicity studies
- Specialized nerve extractions
for neuroscientific studies
- Specialized equipment:
Faxitron Digital Imaging
Use of the pathology module
of Provantis™ enables data collection
to be done at computerized work stations
within this integrated laboratory.
For more detailed information
about the pathology services offered by MPI
Research, please contact Pathology@mpiresearch.com or
call 269.668.3336, Ext. 1212.
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