The MPI Research Department
of Infusion Toxicology has the expertise
and technology to conduct intravenous infusion
(IV) studies in mice, rats, rabbits, dogs,
mini-pigs, and non-human primates. The preclinical
safety evaluation of a drug via intravenous
infusion is typically used to mimic the route
of administration and dose regimen intended
for human use.
Difficulties encountered with drugs of poor
solubility and/or poor bioavailability when
administered via another route can necessitate
the use of IV infusion to achieve higher
systemic multiples of the clinical dose and/or
to control the Cmax value.
The IV infusion allows for larger volumes
to be administered over a longer period of
time. By adjusting concentration and dose
volume, it is possible to increase the tolerability
of a drug. The use of a larger blood vessel
such as the vena cava also permits a greater
dilution of the drug and reduces the potential
for irritation due to a low or high pH.
Based on the intended duration of treatment
(i.e., from a few minutes up to a continuous
24 hours/day), dosing can be either performed
in restrained animals via a peripheral vein
or using the jacket tether system. For the
latter, a medical-grade catheter is implanted
in the vena cava via the femoral vein, or into
the jugular vein, then passed subcutaneously
and exteriorized in the back of the animal.
The catheter is passed through the tether and
connected to a rotating swivel attached to
the cage, which allows the animal to move freely.
On the opposite side of the swivel, short tubing
with an injection cap is connected to the syringe
or volumetric infusion pump.
Services/Capabilities
- Choices based on the degree of infusion
flexibility desired are available; either
an ambulatory (often preferred for intermittent
dosing) or a tether infusion system (for
long-term and continuous infusion) can
be used, based on study design
- Customized study designs that permit
changes to be made easily, quickly, and
accurately based upon sponsor request
- Acute, subchronic, and chronic toxicology
studies
- Animal models utilizing rats, rabbits,
dogs, minipigs, and non-human primates
- Large animal surgery within the Infusion
Toxicology laboratory, with complete and
ready access to the entire MPI surgical
team and facilities
- Enthusiastic team committed to assuring
that Sponsor needs are met
For more detailed information about the
infusion toxicology services offered by MPI
Research, please contact Infusiontoxicology@mpiresearch.com or
call 269.668.3336, Ext. 1710.
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