The company has conducted numerous preclinical studies in virtually all therapeutic areas for private industry and government. The roster of basic study outlines in this section provides a closer look at the research process at MPI. More information about these studies or custom studies is available by contacting the Study Director responsible for that area.

Individual study outlines can be viewed by clicking on the title of the individual study below.

All outlines are in .pdf format. Adobe Reader is required.


General Toxicology

• 2-Week Toxicity Study in Non-Rodents
• 2-Week Toxicity Study in Rats
• 2-Week Toxicity Study in Mice
• 4-Week Toxicity Study in Non-Rodents
• 4-Week Toxicity Study in Non-Rodents Including A 4-Week Recovery Period
• 4-Week Toxicity Study in Rats
• 4-Week Toxicity Study in Rats Including A 4-Week Recovery Period
• 4-Week Toxicity Study in Mice
• 4-Week Toxicity Study in Mice Including A 4-Week Recovery Period
• 13-Week Toxicity Study in Non-Rodents
• 13-Week Toxicity Study in Non-Rodents Including A 4-Week Recovery Period
• 13-Week Toxicity Study in Rats
• 13-Week Toxicity Study in Rats Including A 4-Week Recovery Period
• 13-Week Toxicity Study in Mice
• 13-Week Toxicity Study in Mice Including A 4-Week Recovery Period
• 26-Week Toxicity Study in Rats
• 26-Week Toxicity Study in Rats Including A 4-Week Recovery Period
• 26-Week Toxicity Study in Mice
• 26-Week Toxicity Study in Mice Including A 4-Week Recovery Period
• 39-Week Toxicity Study in Non-Rodents
• 39-Week Toxicity Study in Non-Rodents Including A 4-Week Recovery Period
• 104-Week Chronic Toxicity-Oncogenicity Study in Rats
• 104-Week Oncogenicity Study in Rats
• 104-Week Oncogenicity Study in Mice
• Expanded Acute Toxicity Study in Non-Rodents
• Expanded Acute Toxicity Study in Rats
• Dose Range-Finding Toxicity Study in Non-Rodents
• Dose Range-Finding Toxicity Study in Rats
• Acute Perivascular Irritation Study in Rabbits
• Acute Toxicity Study in Non-Rodents
• Acute Toxicity Study in Rats
• Genetic Toxicology Assays
• Acute (LD50) Dermal Toxicity Study in Rats Or Rabbits
• Eye Irritation Study in Rabbits
• Murine Local Lymph Node Assay (MLLNA) For Assessment of Allergic Contact Dermatitis Potential
• Acute (LD50) Toxicity Study in Rats
• Pyrogenicity Study in Rabbits
• Skin Irritation Study in Rabbits
• Skin Sensitization Study (Buehler Method) in Guinea Pigs
• Skin Sensitization Study (Maximization Method) in Guinea Pigs
• Bioavailability Study in Non-Rodents
• Bioavailability Study in Rats

Infusion Toxicology Study Outlines

• 2-Week Continuous Infusion - Non-Rodent
• 2-Week Continuous Infusion - Rat
• 4-Week Continuous Infusion with Recovery - Non-Rodent
• 4-Week Continuous Infusion with Recovery - Rat
• 4-Week Continuous Infusion - Non-Rodent
• 4-Week Continuous Infusion - Rat
• 13-Week Continuous Infusion with Recovery - Non-Rodent
• 13-Week Continuous Infusion with Recovery - Rat
• 13-Week Continuous Infusion - Non-Rodent
• 13-Week Continuous Infusion - Rat
• DRF Continuous Infusion - Non-Rodent
• DRF Continuous Infusion - Rat

Developmental and Reproductive Toxicology (DART)

• Embryo-Fetal Development in Rabbits
• Embryo-Fetal Development in Rats
• Two-Generation Reproduction
• Rat Fertility and Embryonic Development
• Rabbit Prenatal Developmental Toxicity
• Rat Toxicity — Prenatal, Postnatal, Maternal
• Reproduction/Developmental Toxicity Screening
• Reproduction/Developmental Toxicity Screening — Combined Dose
• One-Generation Reproduction Toxicity
• Rat Developmental Neurotoxicity
• Rabbit Prenatal Developmental Toxicity, Pilot — OECD 414
• Rat Prenatal Developmental Toxicity — OECD 414
• Rabbit Prenatal Developmental Toxicity — OECD 414

Surgery

MPI Research has conducted numerous preclinical, highly customized studies in Surgical Services for private industry and government. Information about these studies is available by contacting:

Mark Johnson, MS
Director, Surgery, Senior Study Director
Phone: (269) 668-3336, Ext. 1375
E-mail: Mark.Johnson@mpiresearch.com

Pathology Services

MPI Research has conducted numerous preclinical, highly customized studies in Pathology Services for private industry and government. Information about these studies is available by contacting:

Theodore Slone, DVM, DACVP
Director, Pathology, Senior Principal Pathologist
Phone: (269) 668-3336, Ext. 1212
E-mail: Ted.Slone@mpiresearch.com

Targeted Discovery Research

MPI Research has conducted numerous preclinical, highly customized studies in Targeted Discovery Research for private industry and government. Information about these studies is available by contacting:

Tina Rogers, PhD, MBA, DABT
Associate Director, Research
Phone: (269) 668-3336, Ext. 1120
E-mail: Tina.Rogers@mpiresearch.com

DMPK

• Crossover Discovery PK Study
• Single Dose Discovery PK Study

Safety Pharmacology

Supplemental Safety Studies

• Rat Renal Safety Study
• Rat Gastric Emptying Study
• Rat GI Propulsion Study

Respiratory Safety Studies

• Canine Respiratory Safety Study
• Primate Respiratory Safety Study
• Rat Respiratory Safety Study

Combined Safety Studies

• Dog CV/Respiratory Study
• Monkey CV/Respiratory Study

Cardiovascular Safety Studies

• Canine Cardiovascular Telemetry Study
• Primate Cardiovascular Telemetry Study
• Rat Cardiovascular Screening Study

CNS Safety Studies

• Rat CNS Safety Study
• Canine CNS Safety Study
• Primate CNS Safety Study

Behavioral Pharmacology Studies

• Rat NHP Drug Discrimination Study
• Rat NHP Self Administration Study
• Rat NHP Drug Dependence Study

In Vitro Safety Pharmacology Studies

• HTS hERG Study
• Blockade of hERG Potassium Channels - compound screening
• Blockade of hERG Potassium Channels - dose response curve
• APD in Canine Cardiac Purkinje Fibers
• Arrhythmia Assessment in Langendorff Isolated Heart Model

Bioanalytical/Analytical Sciences

The MPI Research Bioanalytical/Analytical Sciences group has performed numerous preclinical and clinical, highly customized services for private industry and government. Information about these services is available by contacting:

Kevin Lloyd, BS
General Manager, Bioanalytical/Analytical Sciences
Phone: (269) 668-3336, Ext. 4129
E-mail: Kevin.Lloyd@mpiresearch.com

Immunology

• Rat Toxicity — Satellite animals
• Rat Toxicity — TK animals
• Rat Toxicity — NK and Phenotyping
• Dog Toxicity
• Monkey Toxicity

Molecular Imaging

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