In an effort to help Sponsors meet the ICH S7A guidelines for follow up testing, MPI Research announced their ability to conduct a validated gastric emptying assay in rats. The validation study evaluated the effects of two positive control articles on gastric emptying. Following administration of the positive control articles, the animals received 1.5 ml of phenol red meal. The animals were euthanized approximately 20 minutes after the phenol red meal was administered at which time the stomachs were analyzed for phenol red content. The samples were read spectrophotometrically and compared to a standard curve to determine the concentration of phenol red remaining in the stomachs. In comparison to the control group, there was a decrease in gastric emptying with the administration of CCK-8 and an increase in gastric emptying with metoclopramide.

James Laveglia, Ph.D., Executive Vice President and Director of Research, commented, “We are rapidly expanding our capabilities in Safety Pharmacology. In addition to conducting cardiovascular telemetry studies in rats, dogs and monkeys, we are expanding our pharmacology capabilities and have the ability to conduct studies for neurological, respiratory and renal evaluation.”

MPI Research exists to provide comprehensive non-clinical research that meets the requirements of pharmaceutical, animal health and chemical companies as well as governmental agencies as we partner together to bring safer, healthier products to the world. MPI employees specialize in a wide variety of scientific disciplines including toxicology, pharmacology, metabolism, pathology, clinical pathology, reproductive and developmental biology, veterinary science, neuroscience, analytical chemistry, computer science, regulatory science, and statistics.

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