MPI Research

/MPI Research

About MPI Research

MPI Research, with global headquarters in Mattawan, Mich., provides safety evaluation, discovery, bioanalytical and analytical services to the biopharmaceutical, medical device, animal health, and chemical industries. The company offers comprehensive imaging solutions including preclinical imaging, radiochemistry, and data analysis. Scientific knowledge and experience, responsiveness, integrity, trust, teamwork, and dedication to strong and enduring Sponsor relationships are the defining attributes that characterize MPI Research as a high-performance, high-quality organization that is committed to bringing safer and more effective products to the world.

Surgical and Orthopaedic Insights from Biomechanical Testing

by Shane Woods, Senior Study Director

As surgical procedures advance and treatments become more sophisticated, the need to understand how they affect the body matures. That’s where biomechanical testing can provide keen insights.

Biomechanics combines engineering with biology to help us better understand the complexities of life.  Evaluating bone, cartilage, muscle, tendon and other tissues—how they respond […]

By | 2017-07-04T10:27:16+00:00 April 1st, 2015|Blog|Comments Off on Surgical and Orthopaedic Insights from Biomechanical Testing

What is SEND? A Brief Introduction to the Standard for Exchange of Nonclinical Data

By Christy Kubin, BS, Data Architect (SEND), Brian Argo, BS, Data Architect (SEND), and Jamie Megna, BS, Data Architect (SEND)

SEND is the Clinical Data Interchange Standards Consortium (CDISC), Standard for Exchange of Nonclinical Data (SEND). It is an implementation of the Study Data Tabulation Model (SDTM) for nonclinical studies. This description […]

By | 2017-07-04T10:27:21+00:00 March 18th, 2015|Blog|Comments Off on What is SEND? A Brief Introduction to the Standard for Exchange of Nonclinical Data

Why do Preclinical Humane Endpoints Matter?

by Dale M. Cooper, DVM, MS, DACLAM

When people are suffering or dying from disease, there’s a powerful incentive to move new treatments through the pipeline as quickly as possible. But while speed is important, it cannot come at the expense of quality and compliance.  The care of animals involved in preclinical safety studies is a […]

By | 2017-07-04T10:27:22+00:00 March 11th, 2015|Blog|Comments Off on Why do Preclinical Humane Endpoints Matter?

Making The Most of Biomarkers in Preclinical Studies

by Adam Aulbach, DVM, DACVP

Biomarkers are a useful tool in clinical trials, especially in identifying a drug’s impact on organs or tissues before any injury is clinically evident. It’s still early in their use in preclinical development; however, they are proving helpful in identifying major safety issues and showing promise for future use.

Presently, biomarkers are […]

By | 2017-07-04T10:27:23+00:00 February 25th, 2015|Blog|Comments Off on Making The Most of Biomarkers in Preclinical Studies

The Connection between Inflammation and Cardiovascular Disease

by Mark Johnson, M.S. Senior Director of Surgery

Heart disease is a major cause of morbidity and mortality, particularly in developed nations. Classically, cardiovascular disease (CVD) was thought to be a buildup of fat on the arterial wall that eventually blocks blood flow, leading to a heart attack or stroke. However, the process also involves inflammatory […]

By | 2017-07-04T10:27:23+00:00 February 18th, 2015|Blog|Comments Off on The Connection between Inflammation and Cardiovascular Disease

The Role of Swine as Preclinical Models for Cardiovascular Disease

by Mark Johnson, M.S. Senior Director of Surgery

Classically, pharma, biotech, and device researchers have relied on rodent models to discover and validate disease targets and mechanisms, as well as for the preclinical development of therapeutics. However, the biology of rodents often fails to accurately predict outcomes in patients – perhaps not surprisingly, as mice are […]

By | 2017-07-04T10:27:26+00:00 February 11th, 2015|Blog|Comments Off on The Role of Swine as Preclinical Models for Cardiovascular Disease

Bioanalytical Methods Transfer: Overcoming Data-sharing Challenges

by Roger Hayes, PhD

In a previous blog, I shared my perspective on best practices in bioanalytical methods transfer. Such practices aim to assure quality data across the drug development process. At the same time, they require a […]

By | 2017-07-04T10:27:27+00:00 January 20th, 2015|Blog|Comments Off on Bioanalytical Methods Transfer: Overcoming Data-sharing Challenges

Best Practices for Successful Bioanalytical Methods Transfer

By Roger Hayes, PhD

From bench to bedside, developing a new drug requires many years and many hands. Each step must be taken carefully to ensure the quality and integrity of the process. This is of special importance in bioanalytical methods transfer.

Method transfer involves seamlessly moving a bioanalytical process and the information it generates across different […]

By | 2017-07-04T10:27:27+00:00 January 14th, 2015|Blog|Comments Off on Best Practices for Successful Bioanalytical Methods Transfer

Reducing Clinical Failures through Early DMPK Studies

by Ric Slauter, PhD, DABT

Suppose a baseball team had a player whose batting average was a mere 0.0001. We can safely assume that player won’t last long.

Yet that average is the reality of drug development. Whereas 10,000 compounds might enter the discovery stage, only one is likely to survive to become a marketed medication, according […]

By | 2017-07-04T10:27:29+00:00 January 7th, 2015|Blog|Comments Off on Reducing Clinical Failures through Early DMPK Studies

Microsampling Offers Powerful Advantages

By Roger Hayes, PhD

The adage “a little goes a long way” is an emerging reality in preclinical drug development, where new techniques in micro-volume sample analysis are yielding advantages for drug developers.

Traditionally, sample sizes of blood, plasma or serum needed for toxicokinetic (TK) and pharmacokinetic (PK) analysis often exceeded what’s allowed when using rodents, especially […]

By | 2014-12-17T14:33:32+00:00 December 17th, 2014|Blog|Comments Off on Microsampling Offers Powerful Advantages